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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119690Generated: November 1, 2026

5-Benzyloxy-4-t-butyl-2-(1-octenyl)benzofuran → 4-Tert-butyl-5-hydroxy-2-octylbenzofuran

https://huagongshe.com/reaction/2119690

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Benzyloxy-4-t-butyl-2-(1-octenyl)benzofuranHCID 54308722—
CatalystPalladiumHCID 23938—
SolventAcetic AcidHCID 176—
Product4-Tert-butyl-5-hydroxy-2-octylbenzofuranHCID 2344286470.4%

Reaction Steps

Under hydrogen atmosphere, a solution of 1.1 g of 5-benzyloxy-4-t-butyl-2-(1-octenyl)benzofuran in 50 ml of acetic acid was stirred with 1.1 g of 10% palladium on carbon for 36 hours. After the palladium on carbon was filtered out, the filtrate was concentrated and the concentrate was purified by silica gel column chromatography (in chloroform) to give 0.6 g of 4-t-butyl-5-hydroxy-2-n-octylbenzofuran as a pale yellow oil (yield 69%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06686389B2
Source datasetuspto-grants-2004_02
ORD IDord-240a5819476d4ed7b3828376915ae131
Source noteuspto-grants-2004_02