Cytarabine → 13491-47-9

HRID 2119775Notes

Reaction equation

[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH:15][C:18](=[O:20])[CH3:19])=[N:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]

Participants

Reactant 2

HCID 6253Cytarabine

HCID 7918Acetic Anhydride

Product 1

HCID 8353313491-47-9

Procedure

introducing an acyl group at the N4 position of 1-β-D-arabinofuranosyl cytosine with an acylating agent, for example using acetic anhydride under conditions suitable for obtaining 1-β-D-arabinofuranosyl-N4-acetyl cytosine,

Sources & evidence

ORD record: ord-53fcceddad424ae7b0be80c79fb32a1c
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686463B2

Reaction notes

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