反应详情

温度

110 °C

23.2 g of 4-(4-bromophenyl)-2-(2,6-difluorophenyl)-3-hydroxypyrimidine and 100 ml of POCl3 are mixed and stirred for one hour at 110° C. The reaction mixture is slowly poured into a solution of 250 g of NaOH (solid) in water, and filtered. After dissolving the precipitate in ethyl acetate, drying with magnesium sulfate, filtering and concentrating, the title compound is obtained with a melting point of 146-148° C. (compound 3.354).

1. filtrationfiltered
2. dissolutionAfter dissolving the precipitate in ethyl acetate
3. dry with materialdrying with magnesium sulfate
4. filtrationfiltering
5. concentrationconcentrating