Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | HCID 23443407 | HCID 23443407 | — |
| Reactant | Sodium 2-methylbenzene-1-sulfinate | HCID 23676349 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23443402 | HCID 23443402 | — |
Reaction Steps
6 g of 4-(4-bromophenyl)-2-(2,6-difluorophenyl)-3-chloropyrimidine, 80 ml of dimethylformamide, 1.53 g of KCN and 0.93 g of sodium tolylsulfinate are mixed together, stirred for 3 hours at 80° C., mixed with ice water and filtered. After dissolving the precipitate in ethyl acetate, drying with magnesium sulfate, filtering and concentrating, the title compound is obtained with a melting point 146-148° C. (compound 3.355).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06686469B2 |
|---|
| Source dataset | uspto-grants-2004_02 |
|---|
| ORD ID | ord-d837c67e78654e75abc18bae4b2601f9 |
|---|
| Source note | uspto-grants-2004_02 |
|---|
