Potassium Cyanide → HCID 23443402, compound

HRID 2119788Notes

Reaction equation

HRID 2119788 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9](Cl)[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[C-:23]#[N:24].[K+].C1(C)C=CC=CC=1S([O-])=O.[Na+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([C:23]#[N:24])[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 9032Potassium CyanideHCID 23443407HCID 23443407, compoundHCID 23676349Sodium 2-methylbenzene-1-sulfinate

Product 1

HCID 23443402HCID 23443402, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

6 g of 4-(4-bromophenyl)-2-(2,6-difluorophenyl)-3-chloropyrimidine, 80 ml of dimethylformamide, 1.53 g of KCN and 0.93 g of sodium tolylsulfinate are mixed together, stirred for 3 hours at 80° C., mixed with ice water and filtered. After dissolving the precipitate in ethyl acetate, drying with magnesium sulfate, filtering and concentrating, the title compound is obtained with a melting point 146-148° C. (compound 3.355).

Workup

  1. filtrationfiltered
  2. dissolutionAfter dissolving the precipitate in ethyl acetate
  3. dry with materialdrying with magnesium sulfate
  4. filtrationfiltering
  5. concentrationconcentrating

Sources & evidence

ORD record
ord-d837c67e78654e75abc18bae4b2601f9
Source dataset
uspto-grants-2004_02
Patent number
US06686469B2

Reaction notes

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