2-Aminothiazole → HCID 9900454, compound

HRID 2119790Notes

Reaction equation

HRID 2119790 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[S:10])[CH:7]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 295195-Chloro-2-methylphenyl isothiocyanate

Product 1

HCID 9900454HCID 9900454, compoundYield 77.4%

Procedure

Prepared using Method C from 3.0 g (16.3 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 1.7 g (16.3 mmol) of 2-amino-thiazole to give 3.58 g of title compound as a beige solid, m.p. 197-198° C. (77% yield).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d0612fdc9a5541d0b99810c7b92d3e00
Source dataset
uspto-grants-2004_02
Patent number
US06686476B2

Reaction notes

Loading…