5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-thiazol-2-yl)-thiourea

HRID 2119797Notes

Reaction equation

HRID 2119797 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([CH3:18])[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[S:14][CH:15]=[C:16]([CH3:18])[N:17]=2)=[S:10])[CH:7]=1

Participants

3

Reactant 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 741432-Amino-4-methylthiazole

Product 1

HCID 98358721-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-thiazol-2-yl)-thioureaYield 95%

Procedure

Prepared using Method B from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 2.8 g (24.5 mmol) of 2-amino-4-methylthiazole to give 4.8 g of title compound as an off-white solid (95% yield, m.p. 188° C.).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1735d3cdcbd7495ba0bc92c6e2a1e2eb
Source dataset
uspto-grants-2004_02
Patent number
US06686476B2

Reaction notes

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