HCID 15224449, compound → HCID 15224450, compound

HRID 2119895Notes

Reaction equation

HRID 2119895 reaction equation
[CH2:1]([NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([Cl:16])[C:7]=1[N+:17]([O-])=O)[CH2:2][CH2:3][CH3:4]>[Pt].C1(C)C=CC=CC=1>[NH2:17][C:7]1[C:8]([Cl:16])=[N:9][C:10]2[C:15]([C:6]=1[NH:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:14][CH:13]=[CH:12][CH:11]=2

Participants

4

Reactant 1

HCID 15224449HCID 15224449, compound

Product 1

HCID 15224450HCID 15224450, compoundYield 66.7%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 1140TolueneSolvent

Procedure

4-Butylamino-2-chloro-3-nitroquinoline (33 g, 0.12 mole, Example 112) was combined with toluene (200 mL) and 5% platinum on carbon (1 g). The mixture was hydrogenated on a Parr apparatus at an initial pressure of 38 psi (2.7 Kg/cm2). When the hydrogenation was complete, the catalyst was removed by filtration and the filtrate was concentrated to provide a brown liquid. The liquid was chilled in an ice bath to provide an orange solid. The solid was collected by filtration, slurried with diethyl ether for 30 minutes then filtered to provide 20 g of the desired product as a tan solid. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customto provide a brown liquid
  4. temperatureThe liquid was chilled in an ice bath
  5. customto provide an orange solid
  6. filtrationThe solid was collected by filtration
  7. filtrationthen filtered

Sources & evidence

ORD record
ord-2b9ea487402c4b20b83f5e8c9c1c5cbb
Source dataset
uspto-grants-2004_02
Patent number
US06686472B2

Reaction notes

Loading…