Benzylethanolamine → HCID 10469125, compound

HRID 2119912Notes

Reaction equation

HRID 2119912 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:11]([NH:18][CH2:19][CH2:20][OH:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(OCC)(=O)C>[S:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[N:18]([CH2:19][CH2:20][OH:21])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 4348BenzylethanolamineHCID 119872-Chlorobenzothiazole

Product 1

HCID 10469125HCID 10469125, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Chlorobenzothiazole (13 g) and 2-(benzylamino)ethanol (29 g) were heated together in a sealed vessel at 120° C. for 20 h. After cooling, the reaction mixture was dissolved in ethyl acetate (200 ml) and the solution was washed with saturated aqueous sodium hydrogen carbonate (3×100 ml), water (3×100 ml) and brine (100 ml), dried over anhydrous magnesium sulphate and evaporated to give the title compound (m.p. 95-96° C.; dichloromethane/hexane).

Workup

  1. temperatureAfter cooling
  2. washthe solution was washed with saturated aqueous sodium hydrogen carbonate (3×100 ml), water (3×100 ml) and brine (100 ml)
  3. dry with materialdried over anhydrous magnesium sulphate
  4. customevaporated

Sources & evidence

ORD record
ord-e20ebb49c83f4233919952ecbcc1694c
Source dataset
uspto-grants-2004_02
Patent number
US06686475B2

Reaction notes

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