Water → 3-(Azidomethyl)-5-methyl-1,2-oxazole

HRID 2119945Notes

Reaction equation

HRID 2119945 reaction equation
Br[CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[N-:9]=[N+:10]=[N-:11].[Na+].O>CC(C)=O>[N:9]([CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1)=[N+:10]=[N-:11]

Participants

5

Reactant 3

HCID 962WaterHCID 33557Sodium AzideHCID 27763043-(Bromomethyl)-5-methylisoxazole

Product 1

HCID 234409373-(Azidomethyl)-5-methyl-1,2-oxazole

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of the 3-bromomethyl-5-methyl-isoxazole in acetone is added NaN3 at rt. The reaction mixture is then stirred for about 48 h. Then, the reaction mixture is poured into water and extracted with EtOAc, dried and evaporated.

Workup

  1. extractionextracted with EtOAc
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-d40a14bb0478455e98f221682ad6f4aa
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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