Acetamidine monohydrochloride → 10-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119952Notes

Reaction equation

HRID 2119952 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.Cl.[C:20]([NH2:23])(=[NH:22])[CH3:21]>>[F:17][C:14]1[CH:15]=[CH:16][C:9]2[NH:8][C:7](=[O:18])[CH2:6][C:5]3[CH:4]=[N:22][C:20]([CH3:21])=[N:23][C:11]=3[C:10]=2[CH:13]=1

Participants

3

Reactant 2

HCID 67170Acetamidine monohydrochlorideHCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 2344100610-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 50%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and acetamidine hydrochloride. Yield: 50%.

Sources & evidence

ORD record
ord-95487d93e84f4a20976fb34b46cf20ec
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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