Acetamidine monohydrochloride → 10-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one

Participants

Role	Name	HCID	Charge
Reactant	Acetamidine monohydrochloride	HCID 67170	—
Reactant	4-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione	HCID 66934610	—
Product	10-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one	HCID 23441006	50%

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and acetamidine hydrochloride. Yield: 50%.