Cyclopropanecarboximidamide hydrochloride → 2-Cyclopropyl-10-fluoro-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119955Notes

Reaction equation

CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.Cl.[CH:20]1([C:23]([NH2:25])=[NH:24])[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[N:24]=[CH:4][C:5]3[CH2:6][C:7](=[O:18])[NH:8][C:9]4[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:10]=4[C:11]=3[N:25]=2)[CH2:22][CH2:21]1

Participants

Reactant 2

HCID 2781916Cyclopropanecarboximidamide hydrochloride

HCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 234409812-Cyclopropyl-10-fluoro-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 88%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and cyclopropanecarboxamidine hydrochloride. Yield: 88%.

Sources & evidence

ORD record: ord-961865933d8b4d69969738cdf270c79c
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686352B2

Reaction notes

Loading…