Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119955Generated: October 31, 2026

Cyclopropanecarboximidamide hydrochloride → 2-Cyclopropyl-10-fluoro-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one

https://huagongshe.com/reaction/2119955

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanecarboximidamide hydrochlorideHCID 2781916—
Reactant4-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 66934610—
Product2-Cyclopropyl-10-fluoro-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-oneHCID 2344098188%

Reaction Steps

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and cyclopropanecarboxamidine hydrochloride. Yield: 88%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06686352B2
Source datasetuspto-grants-2004_02
ORD IDord-961865933d8b4d69969738cdf270c79c
Source noteuspto-grants-2004_02