2-(1H-indol-3-yl)ethanimidamide → 10-Fluoro-5,7-dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119958Notes

Reaction equation

HRID 2119958 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:28][C:29]([NH2:31])=[NH:30])=[CH:20]1>>[F:17][C:14]1[CH:15]=[CH:16][C:9]2[NH:8][C:7](=[O:18])[CH2:6][C:5]3[CH:4]=[N:30][C:29]([CH2:28][C:21]4[C:22]5[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=5)[NH:19][CH:20]=4)=[N:31][C:11]=3[C:10]=2[CH:13]=1

Participants

3

Reactant 2

HCID 40466392-(1H-indol-3-yl)ethanimidamideHCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 2344099510-Fluoro-5,7-dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 87%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(1H-indol-3-yl)-acetamidine. Yield: 87%.

Sources & evidence

ORD record
ord-8a5089c385434473884819c0789046bd
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

Loading…