Ethyl 2-aminobenzoate → ethyl 2-amino-5-chlorobenzoate

HRID 2119959Notes

Reaction equation

HRID 2119959 reaction equation
[C:1]([O:10][CH2:11][CH3:12])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[Cl:13][O-].[Na+]>>[CH2:11]([O:10][C:1](=[O:9])[C:2]1[CH:8]=[C:7]([Cl:13])[CH:6]=[CH:5][C:3]=1[NH2:4])[CH3:12]

Participants

3

Reactant 2

HCID 6877Ethyl 2-aminobenzoateHCID 23665760Sodium Hypochlorite

Product 1

HCID 1515287ethyl 2-amino-5-chlorobenzoate

Procedure

Prepared from ethyl anthranilate and sodium hypochlorite (according to M. Okabe and R-C Sun, Tetrahedron, 1995, 51, 1861) to give an off-white solid, mp 80° C., m/z 199.

Workup

  1. customto give an off-white solid, mp 80° C., m/z 199

Sources & evidence

ORD record
ord-eef734f6bc9c4866808a1f7a747adf2a
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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