Hydrochloric Acid → ethyl 2-amino-5-bromobenzoate

HRID 2119965Notes

Reaction equation

HRID 2119965 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl.[CH2:13](O)[CH3:14]>>[CH2:13]([O:5][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([Br:11])[CH:9]=[CH:10][C:2]=1[NH2:1])[CH3:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 798582-Amino-5-bromobenzoic acid

Product 1

HCID 1515283ethyl 2-amino-5-bromobenzoate

Procedure

As in scheme 1 step 1, from 2-amino-5-bromobenzoic acid, ethanol and HCl gas and heating under reflux for 16 h to afford an off-white solid, mp 83° C.

Workup

  1. temperatureunder reflux for 16 h
  2. customto afford an off-white solid, mp 83° C.

Sources & evidence

ORD record
ord-4310f3247c0a49fd84832cf4d8e8b2cd
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

Loading…