2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 10-Bromo-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119967Notes

Reaction equation

HRID 2119967 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.Cl.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]([NH2:31])=[NH:30])=[CH:24][CH:23]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:30][C:29]([CH2:28][C:25]4[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=4)=[N:31][C:7]=3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 66934668HCID 66934668, compound

Product 1

HCID 2344097210-Bromo-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 99%

Procedure

Analogous to Scheme 1, from 7-bromo-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride. Yield: 99%. White solid, m/z (ISP) 410/412 (MH).

Sources & evidence

ORD record
ord-99fa54e1d98f4addb155cd8548a1cac7
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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