5-Methyl-2-thiophenecarboxaldehyde → HCID 69927084, compound

HRID 2120132Notes

Reaction equation

HRID 2120132 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH2:11])=[N:6][CH:5]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:25])(=O)=O.[CH3:27][C:28]1[S:32][C:31]([CH:33]=O)=[CH:30][CH:29]=1>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[C:8]([NH2:10])[C:7]2[N:6]([N:25]=[C:33]([C:31]3[S:32][C:28]([CH3:27])=[CH:29][CH:30]=3)[N:11]=2)[CH:5]=1)=[O:12]

Participants

4

Reactant 3

HCID 616635-Methyl-2-thiophenecarboxaldehydeHCID 9920476Methyl 5,6-diaminopyridine-3-carboxylateHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 69927084HCID 69927084, compound

Procedure

The title compound, MS m/e (%): 289.2 (M+, 100), was prepared in accordance with the general method of example 1 from 5,6-diamino-nicotinic acid methyl ester, O-mesitylene-sulfonylhydroxylamine, and 5-methylthiophene-2-carboxaldehyde. The purification was performed by flash column chromatography on silica eluting with a mixture of ethyl acetate and n-hexane.

Sources & evidence

ORD record
ord-17ee18579ccd4028b3b1247090d8f983
Source dataset
uspto-grants-2004_02
Patent number
US06689790B2

Reaction notes

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