2-Pyridinecarboxaldehyde → HCID 69922783, compound

HRID 2120136Notes

Reaction equation

HRID 2120136 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH2:11])=[N:6][CH:5]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:25])(=O)=O.[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH:33]=O>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[C:8]([NH2:10])[C:7]2[N:6]([N:25]=[C:33]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=3)[N:11]=2)[CH:5]=1)=[O:12]

Participants

4

Reactant 3

HCID 142732-PyridinecarboxaldehydeHCID 9920476Methyl 5,6-diaminopyridine-3-carboxylateHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 69922783HCID 69922783, compound

Procedure

The title compound, MS m/e (%): 270.3 (M+, 100), was prepared in accordance with the general method of example 1 from 5,6-Diamino-nicotinic acid methyl ester, O-mesitylene-sulfonylhydroxylamine, and pyridine-2-carboxaldehyde. The purification was performed by flash column chromatography on silica eluting with a mixture of ethyl acetate and n-hexane.

Sources & evidence

ORD record
ord-69bc615d74ca432b9d4136d3cbf9f008
Source dataset
uspto-grants-2004_02
Patent number
US06689790B2

Reaction notes

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