[1-(Pyridin-4-yl)piperidin-4-yl]methanamine → HCID 9873549, compound

HRID 2120171Notes

Reaction equation

HRID 2120171 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:12](Cl)=[N:13][CH:14]=[C:15]([Cl:17])[CH:16]=2)=[O:10])=[N:6][CH:7]=1.[N:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][CH:28]([CH2:31][NH2:32])[CH2:27][CH2:26]2)=[CH:21][CH:20]=1>C(O)C>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[Cl:17][C:15]1[CH:16]=[C:11]([C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])[C:12]([NH:32][CH2:31][CH:28]2[CH2:27][CH2:26][N:25]([C:22]3[CH:23]=[CH:24][N:19]=[CH:20][CH:21]=3)[CH2:30][CH2:29]2)=[N:13][CH:14]=1

Participants

4

Reactant 2

HCID 10607746[1-(Pyridin-4-yl)piperidin-4-yl]methanamineHCID 23438734HCID 23438734, compound

Product 1

HCID 9873549HCID 9873549, compoundYield 30.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of N-(5-chloropyridin-2-yl)-2,5-dichloropyridine-3-carboxamide (0.807 g, 2.68 mmol) and 1-(4-pyridinyl)piperidine-4-methylamine (510 mg) in ethyl alcohol (5 mL) was heated in a sealed tube for 24 hours. Filtered the solids and purified by RPHPLC. The pure product containing fractions were combined and lyophilized to give 0.1 g of an off-white solid.

Workup

  1. temperaturewas heated in a sealed tube for 24 hours
  2. filtrationFiltered the solids
  3. custompurified by RPHPLC
  4. additionThe pure product containing fractions

Sources & evidence

ORD record
ord-63a25ed5e5f94c63b9a22d64f0ed29cb
Source dataset
uspto-grants-2004_02
Patent number
US06689780B1

Reaction notes

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