HCID 23438706, compound → HCID 23438738, compound

HRID 2120176Notes

Reaction equation

HRID 2120176 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[NH:18][C:19]([CH:21]2[CH2:26][CH2:25][N:24]([CH:27]([CH3:29])[CH3:28])[CH2:23][CH2:22]2)=[O:20])=[O:11])=[N:7][CH:8]=1.FC(F)(F)C(O)=O.[Cl:37]C1C=CC(NC(C2C=NC=CC=2NC(C2CCNCC2)=O)=O)=NC=1>CC(C)=O>[ClH:2].[ClH:37].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[NH:18][C:19]([CH:21]2[CH2:22][CH2:23][N:24]([CH:27]([CH3:29])[CH3:28])[CH2:25][CH2:26]2)=[O:20])=[O:11])=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 23438706HCID 23438706, compoundHCID 23438715HCID 23438715, compound

Product 1

HCID 23438738HCID 23438738, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

By methods substantially equivalent to those described in example 6-C, N-(5-chloropyridin-2-yl)-4-[(1-isopropylpiperidin-4-ylcarbonyl)amino]pyridine-3-carboxamide hydrochloride (0.219 g, 50%) was prepared from N-(5-chloropyridin-2-yl)-4-[(piperidin-4-ylcarbonyl)amino]pyridine-3-carboxamide trifluoroacetate and acetone. The compound was purified by preparative RPHPLC (C18), eluting with a linear gradient of 95/5 to 60/40 (0.01% HCl/acetonitrile) over 200 min.

Workup

  1. customThe compound was purified by preparative RPHPLC (C18)
  2. washeluting with a linear gradient of 95/5 to 60/40 (0.01% HCl/acetonitrile) over 200 min.

Sources & evidence

ORD record
ord-77a13dfb5a5b46bd920f9fbc875e3c47
Source dataset
uspto-grants-2004_02
Patent number
US06689780B1

Reaction notes

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