3,5-Dichlorosalicylaldehyde → HCID 57096104, Verbindung

HRID 2120203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2120203
O=C1CC2C(=CC(NC(C3CCCC3)=O)=CC=2)N1.ClC1C=C(Cl)C=C(C=O)C=1O.[Cl:30][C:31]1[C:32]([OH:57])=[C:33]([CH:53]=[C:54]([Cl:56])[CH:55]=1)[CH:34]=[C:35]1[C:43]2[C:38](=[CH:39][C:40]([NH:44][C:45]([CH:47]3[CH2:51][CH2:50][CH2:49][CH2:48]3)=[O:46])=[CH:41][CH:42]=2)[NH:37][C:36]1=[O:52]>>[Cl:30][C:31]1[C:32]([OH:57])=[C:33]([CH:53]=[C:54]([Cl:56])[CH:55]=1)[CH2:34][CH:35]1[C:43]2[C:38](=[CH:39][C:40]([NH:44][C:45]([CH:47]3[CH2:51][CH2:50][CH2:49][CH2:48]3)=[O:46])=[CH:41][CH:42]=2)[NH:37][C:36]1=[O:52]

Komponenten

4

Edukt 3

HCID 666603,5-DichlorosalicylaldehydeHCID 54077377HCID 54077377, VerbindungHCID 54539339Cyclopentanecarboxylic acid (2-oxo-2,3-dihydro-1H-indol-6-yl)-amide

Produkt 1

HCID 57096104HCID 57096104, VerbindungAusbeute 40 %

Versuchsvorschrift

Cyclopentanecarboxylic acid (2-oxo-2,3-dihydro-1H-indol-6-yl)-amide was condensed with 3,5-dichlorosalicylaldehyde using method B to give a mixture of isomers of cyclopentanecarboxylic acid [3-(3,5-dichloro-2-hydroxy-benzylidene)-2-oxo-2,3-dihydro-1H-indol-6-yl]-amide as an orange solid which was reduced using method D to give 10 mg (40%) of cyclopentanecarboxylic acid [3-(3,5-dichloro-2-hydroxybenzyl)-2-oxo-2,3-dihydro-1H-indol-6-yl]-amide as an off-white crystalline solid.

Aufarbeitung

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Quellen und Nachweise

ORD-Eintrag
ord-0bec4b20e71b433ca039e7b530479732
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06689806B1

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