Oxindole → 3-(5-Isopropyl-4-methoxy-2-methylbenzylidene)-1,3-dihydroindol-2-one

HRID 2120209Notes

Reaction equation

HRID 2120209 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([C:14]1[C:15]([O:23][CH3:24])=[CH:16][C:17]([CH3:22])=[C:18]([CH:21]=1)[CH:19]=O)([CH3:13])[CH3:12]>>[CH:11]([C:14]1[C:15]([O:23][CH3:24])=[CH:16][C:17]([CH3:22])=[C:18]([CH:21]=1)[CH:19]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 321710OxindoleHCID 32761295-Isopropyl-4-methoxy-2-methylbenzaldehyde

Product 1

HCID 540844983-(5-Isopropyl-4-methoxy-2-methylbenzylidene)-1,3-dihydroindol-2-one

Procedure

2-Oxindole was condensed with 5-isopropyl-4-methoxy-2-methylbenzaldehyde using method B to give 0.25 g of 3-(5-Isopropyl-4-methoxy-2-methylbenzylidene)-1,3-dihydroindol-2-one as a yellow-orange solid which was reduced using method E to give 2 g (100%) of 3-(5-isopropyl-4-methoxy-2-methylbenzyl)-1,3-dihydroindol-2-one as a white solid.

Sources & evidence

ORD record
ord-8738a5a55d7b40c1afbae0c7c7f4b36d
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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