Salicylaldehyde → HCID 53973740, compound

HRID 2120212Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:17]=[C:16]3[C:12]([CH2:13][C:14](=[O:18])[NH:15]3)=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[CH:19](=O)[C:20]1[C:21](=[CH:23][CH:24]=[CH:25][CH:26]=1)[OH:22]>>[OH:22][C:21]1[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=1[CH:19]=[C:13]1[C:12]2[C:16](=[CH:17][C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)=[CH:10][CH:11]=2)[NH:15][C:14]1=[O:18]

Participants

Reactant 2

HCID 6998Salicylaldehyde

HCID 105860706-(3-Methoxyphenyl)-1,3-dihydroindol-2-one

Product 1

HCID 53973740HCID 53973740, compound

Procedure

6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one was condensed with salicylaldehyde using method B to give 3-(2-hydroxybenzylidene)-6-(3-methoxyphenyl)-1,3-dihydro-indol-2-one as a yellow solid which was reducted using method E to give 0.03 g (66%) of 3-(2-hydroxy-benzyl)-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one as a white solid.

Sources & evidence

ORD record: ord-474a8eec28b4432b9e790d466a336327
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06689806B1

Reaction notes

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