Water → 2-(benzenesulfonyl)acetamide

HRID 2120280Notes

Reaction equation

HRID 2120280 reaction equation
Br[CH2:2][C:3]([NH2:5])=[O:4].[C:6]1([S:12]([O:14][Na])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O>CN(C=O)C>[C:6]1([S:12]([CH2:2][C:3]([NH2:5])=[O:4])(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 696322-BromoacetamideHCID 178527445HCID 178527445, compound

Product 1

HCID 18103052-(benzenesulfonyl)acetamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of α-bromoacetamide IV in anhydrous DMF, is added PhSO2Na at 0° C. The reaction mixture is stirred for 1 hour at room temperature and is then poured into water. The organic layer is washed with brine, dried over Na2SO4, and evaporated. The residue is purified by silica gel column chromatography to give α-phenylsulfonylacetamide III.

Workup

  1. washThe organic layer is washed with brine
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customThe residue is purified by silica gel column chromatography

Sources & evidence

ORD record
ord-65266f6a96dc47279dedb4650eca1c6a
Source dataset
uspto-grants-2004_02
Patent number
US06689890B2

Reaction notes

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