4-Methylmorpholine → Quinoxaline-2-carboxylic acid (4-benzenesulfonyl-1-benzyl-2-hydroxy-7-methyl-octyl)-amide

Participants

Reaction Steps

To a solution of one equivalent of 2-amino-5-benzenesulfonyl-8-methyl-1-phenyl-nonan-3-ol in methylene chloride is added 1.05 equivalents each of 2-quinoxalinecarboxylic acid, N-methyl morpholine, and O-benzotriazol-1-yl-N,N,N′,N′-teteramethyluronium hexafluorophosphate. The reaction mixture is stirred at ambient temperature for 18 h. After standard aqueous work-up and extraction, followed by concentration and silica gel chromatography the title compound is obtained.

Provenance & Evidence