HRID2120414

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7972

4-Methylmorpholine

C5H11NO

HCID96695

Quinoxaline-2-carboxylic acid

C9H6N2O2

结构：CC(C)CCC(CC(O)C(N)Cc1ccccc1)S(=O)(=O)c1ccccc1

HCID69687892

未命名化合物

PRODUCTS

生成物

结构：CC(C)CCC(CC(O)C(Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)S(=O)(=O)c1ccccc1

HCID86585890

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of one equivalent of 2-amino-5-benzenesulfonyl-8-methyl-1-phenyl-nonan-3-ol in methylene chloride is added 1.05 equivalents each of 2-quinoxalinecarboxylic acid, N-methyl morpholine, and O-benzotriazol-1-yl-N,N,N′,N′-teteramethyluronium hexafluorophosphate. The reaction mixture is stirred at ambient temperature for 18 h. After standard aqueous work-up and extraction, followed by concentration and silica gel chromatography the title compound is obtained.

WORKUP

后处理

extractionAfter standard aqueous work-up and extraction
concentrationfollowed by concentration and silica gel chromatography the title compound
customis obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13dea5d3be684cb6b9d87b1777cb005e
来源数据集: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06689886B2
来源说明: uspto-grants-2004_02

反应 SMILES

[NH2:1][CH:2]([CH:10]([OH:27])[CH2:11][CH:12]([S:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[N:31]=[CH:30][C:29]=1[C:38](O)=[O:39].CN1CCOCC1>C(Cl)Cl>[C:21]1([S:18]([CH:12]([CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:11][CH:10]([OH:27])[CH:2]([NH:1][C:38]([C:29]2[CH:30]=[N:31][C:32]3[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=3)[N:28]=2)=[O:39])[CH2:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)(=[O:20])=[O:19])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1