Tetrabutylammonium Fluoride → HCID 9950686, compound

HRID 2120425Notes

Reaction equation

HRID 2120425 reaction equation
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:47]=[CH:48][C:49]=1[CH2:50][O:51][Si](C(C)(C)C)(C)C)[CH2:31][O:32][C:33]1[CH:34]=[C:35]([CH2:39][CH2:40][CH2:41][CH2:42][C:43]([CH3:46])([OH:45])[CH3:44])[CH:36]=[CH:37][CH:38]=1)(C(C)(C)C)(C)C>C1COCC1>[OH:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:47]=[CH:48][C:49]=1[CH2:50][OH:51])[CH2:31][O:32][C:33]1[CH:34]=[C:35]([CH2:39][CH2:40][CH2:41][CH2:42][C:43]([CH3:46])([OH:45])[CH3:44])[CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 23439846HCID 23439846, compound

Product 1

HCID 9950686HCID 9950686, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In a manner similar to Example 3(I), by reacting 2 ml of tetrabutylammonium fluoride 1M/THF with 490 mg (0.83 mmol) of 6-{3-[3,4-bis-(tert-butyldimethylsilanyloxymethyl)benzyloxy]phenyl}-2-methylhexan-2-ol in 15 ml of THF, after purification on a silica column (ethyl acetate 90-heptane 10), a yellow oil (m=196 mg; Y=66%) is obtained.

Workup

  1. customafter purification on a silica column (ethyl acetate 90-heptane 10)
  2. customa yellow oil (m=196 mg; Y=66%) is obtained

Sources & evidence

ORD record
ord-e5798b4fb75845fd8096d21336aef7cb
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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