HCID 69685923, compound → HCID 57088798, compound

HRID 2120435Notes

Reaction equation

HRID 2120435 reaction equation
CC1(C)[O:7][CH2:6][C:5]2[CH:8]=[C:9]([CH:12]=[CH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([CH3:33])([O:26]C4CCCCO4)[CH3:25])[CH:15]=3)[CH:10]=[CH:11][C:4]=2[O:3]1>C(O)(=O)C.C1COCC1.O>[OH:7][CH2:6][C:5]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])([CH3:25])[CH3:33])[CH:15]=2)[CH:10]=[CH:11][C:4]=1[OH:3]

Participants

5

Reactant 1

HCID 69685923HCID 69685923, compound

Product 1

HCID 57088798HCID 57088798, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 8(k), by reacting 313 mg (0.67 mmol) of 2,2-dimethyl-6-(2-{3-[5-methyl-5-(tetrahydropyran-2-yloxy)hexyl]phenyl}vinyl)-4H-benzo[1.3]dioxin in 10 ml of acetic acid, 5 ml of THF and 2.5 ml of water, and after purification on a silica column (ethyl acetate 40-heptane 60), white crystals (m=91 mg; Y=40%) are obtained. m.p.=130-1° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 40-heptane 60), white crystals (m=91 mg; Y=40%)
  2. customare obtained

Sources & evidence

ORD record
ord-b48b96d3e1a54473aece6a4b1fd53a67
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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