Sulfuric Acid → HCID 67278677, compound

HRID 2120444Notes

Reaction equation

HRID 2120444 reaction equation
S(=O)(=O)(O)O.O1CCCCC1[O:12][C:13]1[CH:14]=[C:15]([CH:26]=[CH:27][C:28]2[CH:29]=[C:30]([CH:34]=[CH:35][CH2:36][CH2:37][CH2:38][CH2:39][C:40]([CH3:43])([OH:42])[CH3:41])[CH:31]=[CH:32][CH:33]=2)[CH:16]=[C:17]([O:19]C2CCCCO2)[CH:18]=1>C1COCC1.O>[OH:42][C:40]([CH3:43])([CH3:41])[CH2:39][CH2:38][CH2:37][CH2:36][CH:35]=[CH:34][C:30]1[CH:29]=[C:28]([CH:27]=[CH:26][C:15]2[CH:14]=[C:13]([OH:12])[CH:18]=[C:17]([OH:19])[CH:16]=2)[CH:33]=[CH:32][CH:31]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 69685832HCID 69685832, compound

Product 1

HCID 67278677HCID 67278677, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 25(d), by reacting 0.037 ml of concentrated sulphuric acid with 374 mg (0.72 mmol) of 8-(3-{2-[3,5-bis(tetrahydropyran-2-yloxy)phenyl]vinyl}phenyl)-2-methyloct-7-en-2-ol in 4 ml of THF and 2 ml of water, after purification on a silica column (ethyl acetate 40-heptane 60), a beige powder (m=40 mg; Y=16%) is obtained. m.p.=152-4° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 40-heptane 60)
  2. customa beige powder (m=40 mg; Y=16%) is obtained

Sources & evidence

ORD record
ord-ad564a2a35f5490ab504545aeef76d58
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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