Sulfuric Acid → HCID 57167140, compound

HRID 2120451Notes

Reaction equation

HRID 2120451 reaction equation
S(=O)(=O)(O)O.[Si]([O:13][CH2:14][C:15]1[CH:16]=[C:17]([CH:30]=[CH:31][C:32]2[CH:33]=[C:34]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][C:43]([CH3:52])([CH3:51])[O:44]C3CCCCO3)[CH:35]=[CH:36][CH:37]=2)[CH:18]=[CH:19][C:20]=1[CH2:21][O:22][Si](C(C)(C)C)(C)C)(C(C)(C)C)(C)C>C1COCC1.O>[OH:13][CH2:14][C:15]1[CH:16]=[C:17]([CH:30]=[CH:31][C:32]2[CH:33]=[C:34]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][C:43]([CH3:52])([OH:44])[CH3:51])[CH:35]=[CH:36][CH:37]=2)[CH:18]=[CH:19][C:20]=1[CH2:21][OH:22]

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 69927532HCID 69927532, compound

Product 1

HCID 57167140HCID 57167140, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 25(d), by reacting 0.56 ml of concentrated sulphuric acid with 2.30 g (3.37 mmol) of 2-[6-(3-{2-[3,4-bis-(tert-butyldimethylsilanyloxymethyl)phenyl]vinyl}phenyl)-1,1-dimethylhexyloxy]tetrahydropyran in 30 ml of THF and 10 ml of water, after purification on a silica column (ethyl acetate 80-heptane 20), white crystals (m=475 mg; Y=38%) are obtained. m.p.=93-5° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 80-heptane 20), white crystals (m=475 mg; Y=38%)
  2. customare obtained

Sources & evidence

ORD record
ord-53c3dccde7d744199c544f748e7a4844
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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