Sulfuric Acid → HCID 57277395, compound

HRID 2120452Notes

Reaction equation

HRID 2120452 reaction equation
S(=O)(=O)(O)O.C([Si](C)(C)[O:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]=[CH:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][C:32]([CH3:41])([O:34]C3CCCCO3)[CH3:33])[CH:22]=2)=[CH:15][CH:14]=1)(C)(C)C>C1COCC1.O>[OH:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([CH:19]=[CH:20][C:21]2[CH:22]=[C:23]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][C:32]([CH3:41])([OH:34])[CH3:33])[CH:24]=[CH:25][CH:26]=2)=[CH:17][CH:18]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 57101785HCID 57101785, compound

Product 1

HCID 57277395HCID 57277395, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 25(d), by reacting 0.2 ml of concentrated sulphuric acid with 1 g (1.86 mmol) of tert-butyldimethyl-[4-(2-{3-[6-methyl-6-(tetrahydropyran-2-yloxy)heptyl]phenyl}vinyl)benzyloxy]silane in 20 ml of THF and 10 ml of water, after purification on a silica column (ethyl acetate 50-heptane 50), white crystals (m=350 mg; Y=56%) are obtained. m.p.=105-7° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 50-heptane 50), white crystals (m=350 mg; Y=56%)
  2. customare obtained

Sources & evidence

ORD record
ord-905bb7f856c14fed9b8168fea11a4d92
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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