Sulfuric Acid → HCID 57113135, compound

HRID 2120461Notes

Reaction equation

HRID 2120461 reaction equation
S(=O)(=O)(O)O.C(OC[O:10][C:11]1[CH:12]=[C:13]([CH:22]=[CH:23][C:24]2[CH:25]=[C:26]([CH:30]=[CH:31][CH2:32][CH2:33][CH:34]([OH:38])[CH:35]([CH3:37])[CH3:36])[CH:27]=[CH:28][CH:29]=2)[CH:14]=[C:15]([O:17]COCC)[CH:16]=1)C>CO.C1COCC1>[OH:38][CH:34]([CH:35]([CH3:37])[CH3:36])[CH2:33][CH2:32][CH:31]=[CH:30][C:26]1[CH:25]=[C:24]([CH:23]=[CH:22][C:13]2[CH:12]=[C:11]([OH:10])[CH:16]=[C:15]([OH:17])[CH:14]=2)[CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 2

HCID 1118Sulfuric AcidHCID 57101221HCID 57101221, compound

Product 1

HCID 57113135HCID 57113135, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Example 1(j), by reacting 0.3 ml of concentrated sulphuric acid in 2.8 ml of methanol with 140 mg (0.31 mmol) of 7-{3-[2-(3,5-bis-ethoxymethoxyphenyl)vinyl]phenyl}-2-methylhept-6-en-3-ol in 2.8 ml of THF, after purification on a silica column (ethyl acetate 40-heptane 60), a white powder (m=80 mg; Y=77%) is obtained. m.p.=51-60° C.

Workup

  1. customafter purification on a silica column (ethyl acetate 40-heptane 60)
  2. customa white powder (m=80 mg; Y=77%) is obtained

Sources & evidence

ORD record
ord-6ebb2bad90474b8d902159987eb94189
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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