Tetrahydrofuran → 4-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-morpholinopyrimidine-5-carboxamide

HRID 212047Notes

Reaction equation

HRID 212047 reaction equation
[C:1]([NH2:2])(=[O:3])[c:4]1[n:5][cH:6][cH:7][c:8]([O:10][c:11]2[c:12]([F:39])[cH:13][c:14]([NH:17][c:18]3[n:19][c:20]([S:35]([CH3:36])(=[O:37])=[O:38])[n:21][cH:22][c:23]3[C:24](=[O:25])[NH:26][c:27]3[c:28]([F:34])[cH:29][c:30]([F:33])[cH:31][cH:32]3)[cH:15][cH:16]2)[cH:9]1.[CH2:40]1[CH2:41][O:42][CH2:43][CH2:44][NH:45]1.[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1>>[C:1]([NH2:2])(=[O:3])[c:4]1[n:5][cH:6][cH:7][c:8]([O:10][c:11]2[c:12]([F:39])[cH:13][c:14]([NH:17][c:18]3[n:19][c:20]([N:45]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[n:21][cH:22][c:23]3[C:24](=[O:25])[NH:26][c:27]3[c:28]([F:34])[cH:29][c:30]([F:33])[cH:31][cH:32]3)[cH:15][cH:16]2)[cH:9]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8083MorpholineHCID 577213594-(4-(2-carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(methylsulfonyl)pyrimidine-5-carboxamide

Product 1

HCID 577213694-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-morpholinopyrimidine-5-carboxamide

Sources & evidence

ORD record
ord-8b75525efee4431fb29676c3a4115008
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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