HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 86586427, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Reactant | 2-(Pyridin-4-yl)acetonitrile | HCID 4112085 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | HCID 86586427 | HCID 86586427 | — |
Reaction Steps
7.52 g (63.7 mmol) of 4-pyridylacetonitrile and 11.09 g (63.7 mmol) of tert-butoxybis(dimethylamino)methane were stirred at 100° C. for 2 h. In the course of this, liberated dimethylamine and t-butanol were led off to the atmosphere by a slight reduced pressure flow by means of a vacuum pump. Flash chromatography (CH2Cl2/ethyl acetate 50:1→20:1) yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693102B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-870af5687530492e8d375befa3db4e26 |
| Source note | uspto-grants-2004_02 |