1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide → HCID 178517574, compound

HRID 2120571Notes

Reaction equation

HRID 2120571 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14](=[NH:16])[NH2:15])=[N:6]1.[N:21]1[CH:26]=[CH:25][C:24]([CH:27]([C:33](OCC)=[O:34])[C:28](OCC)=[O:29])=[CH:23][CH:22]=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[N:15]=[C:28]([OH:29])[C:27]([C:24]3[CH:23]=[CH:22][N:21]=[CH:26][CH:25]=3)=[C:33]([OH:34])[N:16]=2)=[N:6]1

Participants

4

Reactant 2

HCID 114039861-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamideHCID 12661050HCID 12661050, compound

Product 1

HCID 178517574HCID 178517574, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
140 °C

Procedure

3.27 g (12.1 mmol)1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximid-amide from example III were suspended in 40 ml toluene, reacted with 2.88 g (12.1 mmol) diethyl 2-(4-pyridinyl)malonate (commercially available by Mercachem) and stirred overnight at 140° C. For purification the deposited solid is sucked off and dried under high vacuum.

Workup

  1. customFor purification the deposited solid
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-67ad2f981dfa4174ba73ef7bd30ace67
Source dataset
uspto-grants-2004_02
Patent number
US06693102B2

Reaction notes

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