Hydrochloric Acid → HCID 23435828, compound

HRID 2120644Notes

Reaction equation

HRID 2120644 reaction equation
C1(=O)[N:5]([O:6][CH:7]2[CH2:12][CH2:11][O:10][C:8]2=[O:9])C(=O)C2=CC=CC=C12.[ClH:19]>>[ClH:19].[NH2:5][O:6][CH:7]1[CH2:12][CH2:11][O:10][C:8]1=[O:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 135771142-[(2-Oxooxolan-3-yl)oxy]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 23435828HCID 23435828, compound

Procedure

α-Phthalimidooxy-γ-butyrolactone (1.0 g, 4 mmol) was added to hydrochloric acid (1M, 10 mL) at reflux. After 5 min. at reflux for 5 min and the reaction was cooled down on an ice bath and filtered. The filtrate was evaporated to dryness. Toluene was added and residual water removed azeotropic distillation. 0.75 g of the desired material was obtained.

Workup

  1. temperatureat reflux
  2. temperatureAfter 5 min. at reflux for 5 min
  3. temperaturethe reaction was cooled down on an ice bath
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness
  6. additionToluene was added
  7. distillationresidual water removed azeotropic distillation

Sources & evidence

ORD record
ord-8fdff8b547474b39bca7defe841a5fb8
Source dataset
uspto-grants-2004_02
Patent number
US06693111B1

Reaction notes

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