Hydrochloric Acid → 3,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine-6-pentanoic acid

HRID 2120656Notes

Reaction equation

HRID 2120656 reaction equation
C([O:5][C:6](=[O:21])[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]2[O:15][CH2:16][CH2:17][NH:18][C:19]=2[N:20]=1)CCC.[OH-].[Na+].Cl>CO>[O:15]1[CH2:16][CH2:17][NH:18][C:19]2[N:20]=[C:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:6]([OH:21])=[O:5])[CH:12]=[CH:13][C:14]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20622482HCID 20622482, compound

Product 1

HCID 234355083,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine-6-pentanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-6 (0.223 mmol) and 1.0 N NaOH solution (0.268 mL, 0.268 mmol) in MeOH (1.5 mL) was stirred overnight. The reaction was neutralized by adding 1.0 N HCl solution (0.268 mL, 0.268 mmol) then concentrated and used in Step G without further purification.

Workup

  1. concentrationthen concentrated
  2. customused in Step G without further purification

Sources & evidence

ORD record
ord-5f13dcf564ff4d9093aa0f2f39ec0516
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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