Hydrochloric Acid → HCID 10181305, compound

HRID 2120661Notes

Reaction equation

HRID 2120661 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH:6]([C:24]1[CH:25]=[N:26][C:27]2[C:32]([CH:33]=1)=[CH:31][CH:30]=[CH:29][CH:28]=2)[NH:7][C:8](=[O:23])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]2[NH:21][CH2:20][CH2:19][NH:18][C:17]=2[N:22]=1)C.[OH-].[Na+].Cl>CCO>[N:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:33]=[C:24]([CH:6]([NH:7][C:8](=[O:23])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]3[NH:21][CH2:20][CH2:19][NH:18][C:17]=3[N:22]=2)[CH2:5][C:4]([OH:34])=[O:3])[CH:25]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20622487HCID 20622487, compound

Product 1

HCID 10181305HCID 10181305, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-8 (0.141 g, 0.305 mmol) and 1.0 N NaOH solution (0.367 mL, 0.367 mmol) in EtOH (1.5 mL) was stirred overnight. The reaction was neutralized by adding 1.0 N HCl solution (0.0.367 mL, 0.367 mmol) then concentrated. Preparative HPLC followed by lyophilization yielded a yellow solid.

Workup

  1. concentrationthen concentrated
  2. customyielded a yellow solid

Sources & evidence

ORD record
ord-14f993cc2258458c8e3b1b5e2b34883c
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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