反应详情

温度

50 °C

To a solution of 6-10 (1.6 g, 3.37 mmol) in methanol (30 mL) was added paraformaldehyde (0.80 g) and acetic acid (0.96 mL, 16.8 mmol). After stirring at 50° C. for 15 minutes, NaCNBH3 (0.275 g, 4.38 mmol) was added and the mixture stirred for an additional 30 minutes at 50° C. Evaporation of the solvents and purification on silica gel (5% MeOH/CHCl3) afforded 6-10 in 75% yield.

1. stirringthe mixture stirred for an additional 30 minutes at 50° C
2. customEvaporation of the solvents and purification on silica gel (5% MeOH/CHCl3)
3. customafforded 6-10 in 75% yield