HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 10-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 10-tert-Butoxycarbonylamino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester | HCID 20622486 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 10-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester | HCID 20622483 | 104.8% |
Reaction Steps
A solution of 24-6 (495 mg, 1.21 mmol) in ethyl acetate (3 mL) was treated with a saturated solution HCl in ethyl acetate (10 mL) at room temperature overnight. The solvent was removed in vacuo to afford 24-7 (390 mg). The crude product was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693101B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-8d12a16d6ff24a63aca90859fb37a268 |
| Source note | uspto-grants-2004_02 |