Hydrochloric Acid → 10-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester

HRID 2120705Notes

Reaction equation

HRID 2120705 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH:6]([C:22]1[CH:23]=[N:24][C:25]([CH3:28])=[N:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(OC(C)(C)C)=O)[CH3:2].Cl>C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH:6]([C:22]1[CH:23]=[N:24][C:25]([CH3:28])=[N:26][CH:27]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2062248610-tert-Butoxycarbonylamino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl ester

Product 1

HCID 2062248310-Amino-3-(2-methyl-pyrimidin-5-yl)-decanoic acid ethyl esterYield 104.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 24-6 (495 mg, 1.21 mmol) in ethyl acetate (3 mL) was treated with a saturated solution HCl in ethyl acetate (10 mL) at room temperature overnight. The solvent was removed in vacuo to afford 24-7 (390 mg). The crude product was used directly in the next reaction.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-8d12a16d6ff24a63aca90859fb37a268
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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