HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Methyl-3-phenylisoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate | HCID 727920 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | 72% |
Reaction Steps
To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693108B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-759782c99ed64ee299dbfffe8399244d |
| Source note | uspto-grants-2004_02 |