Water → 23133-34-8

HRID 2120929Notes

Reaction equation

HRID 2120929 reaction equation
[C:1]([C:11]1[O:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:14][N:15]=1)(=O)[C:2]1[CH:7]=[CH:6][C:5](OC)=[CH:4]C=1.I.[OH2:23]>>[C:16]1([C:13]2[O:12][C:11]([C:1]3[CH:2]=[CH:7][C:6]([OH:23])=[CH:5][CH:4]=3)=[N:15][N:14]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 962WaterHCID 24841Hydrogen iodideHCID 69882730HCID 69882730, compound

Product 1

HCID 74519223133-34-8

Conditions

Temperature
130 °C

Procedure

3.5 g (13.89 mmol) of 2-(p-anisoyl)5-phenyl 1,3,4-oxadiazole and 100 mL of concentrated HI aqueous solution was mixed under nitrogen and refluxed at 130° C. for 12 hours. The mixture was cooled down to room temperature and 100 mL of deionized water was added. The precipitate was collected by filtration and dried under vacuum, p-(5-phenyl-1,3,4-oxadiazole-2-yl) phenol was obtained. 1H-NMR (acetone-d6, ppm) δ9.26 (s, 1H), δ8.15 (m, 2H), δ8.06 (d, 2H), δ7.62 (m, 3H), δ7.07 (d, 2H); mp 256.5° C.

Workup

  1. temperatureThe mixture was cooled down to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-8e5a2e8e986e445bafa2f0fc12ff41b3
Source dataset
uspto-grants-2004_02
Patent number
US06693158B2

Reaction notes

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