Trifluoroacetic acid → HCID 69843012, compound

HRID 2120969Notes

Reaction equation

HRID 2120969 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][N:9]2[CH2:29][CH2:28][C:12]3([CH2:17][C:16](=[O:18])[N:15]([CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[C:14](=[O:27])[CH2:13]3)[CH2:11][CH2:10]2)=[CH:3][CH:2]=1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[N:1]1[CH:2]=[CH:3][C:4]([CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][C:12]3([CH2:13][C:14](=[O:27])[N:15]([CH2:19][C:20]([OH:22])=[O:21])[C:16](=[O:18])[CH2:17]3)[CH2:28][CH2:29]2)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22975785HCID 22975785, compound

Product 1

HCID 69843012HCID 69843012, compound

Procedure

0.1 g (0.25 mmol) of the ester from Step C were stirred in 2 ml trifluoroacetic acid at room temperature for 30 minutes. The solvent was removed in vacuo, and the remaining title compound was purified by treating with ethanol and dichloromethane, successively, which was removed under reduced pressure.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe remaining title compound was purified
  3. additionby treating with ethanol and dichloromethane
  4. customsuccessively, which was removed under reduced pressure

Sources & evidence

ORD record
ord-b71ae995846f4658a339c940abccdb0c
Source dataset
uspto-grants-2004_02
Patent number
US06693109B2

Reaction notes

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