HCID 22975785, compound → HCID 86757405, compound

HRID 2120970Notes

Reaction equation

HRID 2120970 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][N:9]2[CH2:29][CH2:28][C:12]3([CH2:17][C:16](=[O:18])[N:15]([CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[C:14](=[O:27])[CH2:13]3)[CH2:11][CH2:10]2)=[CH:3][CH:2]=1>C(O)(=O)C.O=[Pt]=O>[C:20]([OH:22])(=[O:21])[CH3:19].[C:20]([OH:22])(=[O:21])[CH3:19].[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][C:12]3([CH2:17][C:16](=[O:18])[N:15]([CH2:19][C:20]([OH:22])=[O:21])[C:14](=[O:27])[CH2:13]3)[CH2:28][CH2:29]2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 22975785HCID 22975785, compound

Product 1

HCID 86757405HCID 86757405, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

To a solution of 0.5 g (1.25 mmol) of the compound from Example 26, Step C in 40 ml 90% acetic acid were added 100 mg PtO2. The mixture was filled into an autoclave and hydrogenated at 20 atm and room temperature for 22 h. The solvent was removed under reduced pressure, and the residue was stirred with ether. The insoluble title compound was separated and dried in vacuo.

Workup

  1. additionThe mixture was filled into an autoclave and hydrogenated at 20 atm and room temperature for 22 h
  2. customThe solvent was removed under reduced pressure
  3. customThe insoluble title compound was separated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-612404b9802343ed94d02563488abc33
Source dataset
uspto-grants-2004_02
Patent number
US06693109B2

Reaction notes

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