Diisopropylethylamine → 4-[6-(3-Chloro-4-fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][c:16]([Cl:28])[n:17][c:18](-[c:20]3[cH:21][c:22]([Cl:27])[c:23]([F:26])[cH:24][cH:25]3)[cH:19]2)[CH2:12][CH2:13]1.[CH2:29]([CH2:30][CH3:31])[N:32]1[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]1.[CH:38]([N:39]([CH2:40][CH3:41])[CH:42]([CH3:43])[CH3:44])([CH3:45])[CH3:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][c:16]([N:35]3[CH2:34][CH2:33][N:32]([CH2:29][CH2:30][CH3:31])[CH2:37][CH2:36]3)[n:17][c:18](-[c:20]3[cH:21][c:22]([Cl:27])[c:23]([F:26])[cH:24][cH:25]3)[cH:19]2)[CH2:12][CH2:13]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-c89f8d2ed4c54d9595879c0c0f7ccfa0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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