HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Carboxy-2-phenylbenzoyl methionine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tesmilifene Hydrochloride | HCID 175534 | — |
| Reactant | (2-Phenyl4bromobenzoyl)-methionine methyl ester | HCID 20622824 | — |
| Reactant | HCID 178418416 | HCID 178418416 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Carboxy-2-phenylbenzoyl methionine methyl ester | HCID 20622825 | — |
Reaction Steps
A solution of 4-bromo-2-phenylbenzoyl methionine methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693123B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-b24bfde68550426bb41e74359d54e3ad |
| Source note | uspto-grants-2004_02 |