Water → 4-Carboxy-2-phenylbenzoyl methionine methyl ester

HRID 2121133Notes

Reaction equation

HRID 2121133 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CCN(CC[O:33][C:34]1C=CC(CC2C=CC=CC=2)=CC=1)CC.Cl.[C]=[O:49].O>CN(C=O)C.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10]([C:34]([OH:33])=[O:49])=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 962WaterHCID 175534Tesmilifene HydrochlorideHCID 20622824(2-Phenyl4bromobenzoyl)-methionine methyl esterHCID 178418416HCID 178418416, compound

Product 1

HCID 206228254-Carboxy-2-phenylbenzoyl methionine methyl ester

Reagents, catalysts & solvents 2

HCID 167845palladium(II) acetateCatalystHCID 6228DimethylformamideSolvent

Procedure

A solution of 4-bromo-2-phenylbenzoyl methionine methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.

Workup

  1. extractionextracted with ethyl acetate which
  2. customis dried
  3. customevaporated
  4. customThe product is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-b24bfde68550426bb41e74359d54e3ad
Source dataset
uspto-grants-2004_02
Patent number
US06693123B2

Reaction notes

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